Fluoxetine Regulates Ig Kappa Chain C Region Expression Levels in the Serum of Obsessive-Compulsive Disorder Patients: A proteomic Approach
نویسندگان
چکیده مقاله:
Obsessive-Compulsive Disorder (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexity of OCD underlying mechanisms. Here, by the application gel-based proteomic approach the proteome profile of patients with washing subtype of OCD before and after treatment with Fluoxetine (positive responders) are compared to healthy matched controls. However, only one of the differentially expressed proteins is examined and introduced in this paper. Proteomic analysis was by the application of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), combined with (MALDI-TOF-TOF MS)-based. Furthermore, Cytoscape Plug-in, CluePedia, conducted network analysis and biological annotation. The proteome comparison between groups identified protein with the significant expression changes (p
منابع مشابه
Serum Proteomic Profiling of Obsessive-Compulsive Disorder, Washing Subtype: A Preliminary Study
Introduction: Obsessive-Compulsive Disorder (OCD) is a disabling mental condition that its proteomic profiling is not yet investigated. Proteomics is a valuable tool to discover biomarker approaches. It can be helpful to detect protein expression changes in complex disorders such as OCD. Methods: Here, by the application of 2D gel electrophoresis (2DE), a pilot study of serum proteome profile ...
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discipline of medical profession) by the IPSs of the states, when compiled and edited would form an excellent reference work, and can be published. Such a reference work will also become a basis in future to argue that the postgraduate students of every discipline need 2 to 3 months' posting in psychiatry. I hope that the profession will rise to the occasion and achieve the desirable end result.
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BACKGROUND Obsessive-compulsive disorder typically begins early in life and has a chronic course. Despite the need for long-term treatment, the information about therapeutic effect on different clinical subtypes is limited. METHODS Consecutive outpatients with obsessive-compulsive disorder were evaluated for response to a two-month fluoxetine therapy course by Yale-Brown obsessive-compulsive ...
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عنوان ژورنال
دوره 16 شماره 3
صفحات 1264- 1271
تاریخ انتشار 2017-07-01
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